Nowadays, due to the boom that CBD or Cannabidiol is having, there are many people seeking information about this powerful Cannabis, and little by little and thanks to science, it has been shown how effective it can be for the treatment of various diseases.
From severe pain to helping reduce epileptic seizures, this medication can do this and more. But have you asked yourself, how does it work? Or how does it manage to provide so many benefits to the body?
In this article we will answer these and other questions that usually appear when talking about CBD, how does the endocannabinoid system work? We will talk about how Cannabidiol connects with the different ECS receptors in the body to improve your lifestyle and some other aspects that may be of great interest to those who want to learn more about this Cannabis compound.
What is the Endocannabinoid System and how does it work?
Our body is made up of different systems that are responsible for making everything work correctly. All people, or at least the vast majority, have heard of the nervous, digestive, renal and hormonal systems, but few have knowledge about the endocannabinoid system, this is because it is a relatively new discovery of which studies continue to be carried out to learn more about it.
We can tell you that the endocannabinoid system or ECS is responsible for carrying out vital functions such as regulate body temperature, maintain stable glucose levels, regulate respiratory rate, as well as blood pressure, among others.
Through studies it has been determined that cannabinoids act as neurotransmitters for motor learning, pain, appetite and many other processes. This system has several receptors, of which the two main ones are CB1 and CB2, located in the brain and nervous system.
CB1 receptors do not couple to CBD, but they do couple to THC, and these are associated with areas such as the hypothalamus, amygdala and nerve endings, causing the effects that we have already mentioned above.
CB2 receptors are capable of binding to CBD and are found in some parts of the immune system and the peripheral nervous system, acting in a way that reduces inflammation as a response of the immune system.
The endocannabinoid system through CB1 receptors (Head) to CB2 receptors (Body) sends signals that are transmitted throughout the body.
When the CB1 receptors come into contact with THC, it causes psychoactive effects that cannot be obtained with CBD since this compound does not have the affinity with this receptor, and that is why it cannot cause these effects. On the other hand, when the CB2 receptors are under the effects of the CBD compound, leaving a relaxing sensation in the body.
The 5TH1A Receptor (Serotonin) and its role with CBD.
Although the main endocannabinoid receptors are CB1 and CB2, there are others that are extremely important so that all the processes associated with the ECS can be carried out correctly, among them is 5HT1A. This receptor is responsible for exciting or inhibiting neurotransmitters such as glutamate and glutamine, as well as hormones produced by the hypothalamus, adrenal gland, mammary glands and some others, regulating various processes carried out by them.
This receptor is directly associated with the regulation of mood, and different behaviors such as aggression, heart rate, impulsivity, anxiety, and many more.
Now when we talk about CBD it is good to note that this is an excellent anxiolytic, which, when it comes into contact with the 5HT1A receptors, slows down the signals sent, thus reducing the levels of anxiety, as well as reduces depression, epileptic seizures, nausea and pain.
CBD and the TRPV1 receptor
The TRPV1 receptor is activated by Anandamide, an endocannabinoid that studies have shown is related to hunger, sleep and pain reduction, as well as playing an important role in the development of the human embryo.
This receptor is part of the Vanilloid receptor family and binds directly to CBD, causing a therapeutic effect, helping to reduce acute pain, the antiseptic and analgesic properties of both the receptor and the CBD are also increased.
GPR55 receptor and PPARS, how do they work with CBD?
Some scientists consider that this other receptor should be called CB3, because through a study it was possible to observe the amino acid sequence similar to that of the main endocannabinoids CB1 and CB2.
According to some scientists, it is believed that GPR55 is a trigger for epileptic seizures, and there is also strong evidence that it is a proliferator of cancer cells of any type. They have enough evidence that this is one of the causes of the crises, which is why scientists around the world still have it under the microscope.
On the other hand, when GPR55 comes into contact with CBD, it is blocked, which links CBD with effective treatments for breast cancer, pancreas, colon, brain tumors and some others.
When we talk about the PPARS receptor, we are referring to the complete opposite of GPR55, because PPARS is anticancer, which implies that it not only helps reduce the proliferation of Cancer cells, but also plays a fundamental role in the regression of lung cancer.
This receptor is linked to metabolic processes such as lipid absorption, insulin sensitivity and more. When this receptor comes into play with CBD, it degrades beta-amyloid plaque, a molecule that helps the development of Alzheimer's disease, this means that CBD is effective in helping Alzheimer's patients.
How does the Brain act in the presence of CBD?
The human brain is one of the most complex organs that exists, which is why studies never stop to understand this fundamental part of the body that keeps us standing. Every time a substance is ingested or consumed in any other way, it has both positive and negative effects on the brain.
Nowadays, there are many studies that are carried out to understand the effects of cannabinoids, especially emphasizing research based on the effects produced by Cannabidiol. This cannabis compound demonstrates day after day that it is an effective treatment for many diseases due to the how it acts with the different receptors in the body.
This compound helps regulate many important functions of the body, as well as limit the growth of terminal diseases, giving patients a longer lifespan.
CBD continues to grow in the world of medicine, and as studies on how this compound works progress, it is expected that there will continue to be discoveries that favor Cannabidiol and that treatments can be developed for more diseases.